Immune modulating effects of receptor interacting protein 2 (RIP2) in autoinflammation and immunity

Clin Immunol. 2021 Feb:223:108648. doi: 10.1016/j.clim.2020.108648. Epub 2020 Dec 11.

Abstract

Receptor-interacting protein 2 (RIP2) is a kinase that is involved in downstream signaling of nuclear oligomerization domain (NOD)-like receptors NOD1 and 2 sensing bacterial peptidoglycans. RIP2-deficiency or targeting of RIP2 by pharmaceutical inhibitors partially ameliorates inflammatory diseases by reducing pro-inflammatory signaling in response to peptidoglycans. However, RIP2 is widely expressed and interacts with several other proteins suggesting additional functions outside the NOD-signaling pathway. In this review, we discuss the immunological functions of RIP2 and its possible role in autoinflammation and immunity.

Keywords: Apoptosis-associated speck-like protein containing a CARD (ASC); Caspase-1; IL-1β; Inflammasome; Interleukin-1 converting enzyme; NLRP3; NOD1; NOD2; RIPK2.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / metabolism*
  • Autoimmunity
  • Humans
  • Immunity
  • Immunomodulation
  • Inflammation / immunology
  • Inflammation / metabolism*
  • NLR Family, Pyrin Domain-Containing 3 Protein / metabolism
  • Peptidoglycan / immunology
  • Protein Serine-Threonine Kinases / metabolism*
  • Signal Transduction

Substances

  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Peptidoglycan
  • Ral-interacting kinase, human
  • Protein Serine-Threonine Kinases