Peniterpenoids A-C, new sesquiterpenoid metabolites from a wheat cyst nematode Penicillium janthinellum

Sushi Liu; Wenwen Fan; Jinwei Ren; Wenzhao Wang; Xingzhong Liu; Yonghong Liang; Tao Wei; Erwei Li

doi:10.1016/j.fitote.2020.104801

Peniterpenoids A-C, new sesquiterpenoid metabolites from a wheat cyst nematode Penicillium janthinellum

Fitoterapia. 2021 Jan:148:104801. doi: 10.1016/j.fitote.2020.104801. Epub 2020 Dec 10.

Authors

Sushi Liu¹, Wenwen Fan², Jinwei Ren², Wenzhao Wang², Xingzhong Liu², Yonghong Liang³, Tao Wei⁴, Erwei Li⁵

Affiliations

¹ Beijing Key Laboratory of Bioactive Substance and Functional Foods, Beijing Union University, Beijing 100191, China; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
² State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
³ Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
⁴ Beijing Key Laboratory of Bioactive Substance and Functional Foods, Beijing Union University, Beijing 100191, China. Electronic address: weitao@buu.edu.cn.
⁵ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: liew@im.ac.cn.

PMID: 33309650
DOI: 10.1016/j.fitote.2020.104801

Abstract

Three new sesquiterpenoids, peniterpenoids A - C (1-3), together with six known metabolites (4-9) were isolated from an entomogenous fungus Penicillium janthinellum (LB1.20090001) collected from a wheat cyst nematode. The structures of the new compounds were elucidated based on NMR and HRESIMS spectroscopic analyses. The absolute configuration of the C-8 secondary alcohol of peniterpenoid B (2) was determined by [Rh₂(OCOCF₃)₄]-induced ECD experiment. Subsequently, the antimicrobial and DPPH scavenging activities were determined. Compounds 6-8 exhibited moderate antibacterial activities against Staphylococcus aureus (CGMCC1.2465) with MIC values of 25.0, 50.0 and 12.5 μg/mL, respectively.

Keywords: Antibacterial activity; Entomogenous fungus; Penicillium janthinellum; Sesquiterpenoid.

MeSH terms

Animals
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology*
China
Microbial Sensitivity Tests
Molecular Structure
Nematoda / microbiology*
Penicillium / chemistry*
Sesquiterpenes / isolation & purification
Sesquiterpenes / pharmacology*
Staphylococcus aureus / drug effects
Triticum / parasitology*

Substances

Anti-Bacterial Agents
Sesquiterpenes

Supplementary concepts

Penicillium janthinellum