Strategies to improve performances of LSPR biosensing: Structure, materials, and interface modification

Tianping Xu; Zhaoxin Geng

doi:10.1016/j.bios.2020.112850

Strategies to improve performances of LSPR biosensing: Structure, materials, and interface modification

Biosens Bioelectron. 2021 Feb 15:174:112850. doi: 10.1016/j.bios.2020.112850. Epub 2020 Nov 25.

Authors

Tianping Xu¹, Zhaoxin Geng²

Affiliations

¹ School of Information Engineering, Minzu University of China, Beijing, 100081, PR China.
² School of Information Engineering, Minzu University of China, Beijing, 100081, PR China; State Key Laboratory for Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, 100083, PR China. Electronic address: zxgeng@muc.edu.cn.

PMID: 33309521
DOI: 10.1016/j.bios.2020.112850

Abstract

Due to the unique nature of localized surface plasmon resonance (LSPR), LSPR has attracted extensive attention in the field of biochemical sensing. However, compared with other sensors, the LSPR biosensor has lower sensitivity which has the limitation of insufficient repeatability and greatly limits its application and further promotion. Many researchers have invested a lot of energy in various ways to investigate different methods to improve sensitivity. This review summarizes these methods from the three aspects of structure, material, and interface modification. Meanwhile, it can be predicted that the strategies to improve the performance of LSPR biosensing will extend its application.

Keywords: Biosensor; Localized surface plasmon resonance; Plasmonics; Sensitivity.

Publication types

Review

MeSH terms

Biosensing Techniques*
Surface Plasmon Resonance*