Using Genetics To Dissect SARS-CoV-2 Infection

Patrick Brest; Baharia Mograbi; Paul Hofman; Gerard Milano

doi:10.1016/j.tig.2020.11.007

Using Genetics To Dissect SARS-CoV-2 Infection

Trends Genet. 2021 Mar;37(3):203-204. doi: 10.1016/j.tig.2020.11.007. Epub 2020 Nov 26.

Authors

Patrick Brest¹, Baharia Mograbi², Paul Hofman³, Gerard Milano⁴

Affiliations

¹ Université Côte d'Azur, Institute of Research on Cancer and Aging in Nice (IRCAN), Centre Antoine Lacassagne, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Fédération Hospitalo-Universitaire (FHU) OncoAge, F-06189 Nice, France. Electronic address: Patrick.BREST@univ-cotedazur.fr.
² Université Côte d'Azur, Institute of Research on Cancer and Aging in Nice (IRCAN), Centre Antoine Lacassagne, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Fédération Hospitalo-Universitaire (FHU) OncoAge, F-06189 Nice, France.
³ Université Côte d'Azur, Institute of Research on Cancer and Aging in Nice (IRCAN), Centre Antoine Lacassagne, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Fédération Hospitalo-Universitaire (FHU) OncoAge, F-06189 Nice, France; Université Côte d'Azur, Centre Hospitalier Universitaire (CHU) de Nice, Laboratory of Clinical and Experimental Pathology, FHU OncoAge, Hospital-Integrated Biobank (BB-0033-00025), F-06001 Nice, France.
⁴ Université Côte d'Azur, Centre Antoine Lacassagne, Unité Propre de Recherche 7497 Université Côte d'Azur, F-06100 Nice, France. Electronic address: gerard.milano@nice.unicancer.fr.

Abstract

To uncover the key cellular pathways associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity, Daniloski and coworkers used CRISPR-based whole-genome screening. Their results could propose new or repositioned drugs for the ongoing fight against COVID-19.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiotensin-Converting Enzyme 2 / genetics*
Angiotensin-Converting Enzyme 2 / metabolism
COVID-19 / genetics*
COVID-19 / metabolism
COVID-19 / virology
CRISPR-Cas Systems
Gene Editing / methods
Gene Expression
Genome, Viral / genetics*
Genome-Wide Association Study / methods*
Humans
RNA Interference
SARS-CoV-2 / genetics*
SARS-CoV-2 / metabolism
SARS-CoV-2 / physiology

Substances

ACE2 protein, human
Angiotensin-Converting Enzyme 2