Synthesis, spectroscopic and molecular docking studies on new schiff bases, nucleosides and α-aminophosphonate derivatives as antibacterial agents

Saad H Alotaibi; Hamada H Amer

doi:10.1016/j.sjbs.2020.09.061

Synthesis, spectroscopic and molecular docking studies on new schiff bases, nucleosides and α-aminophosphonate derivatives as antibacterial agents

Saudi J Biol Sci. 2020 Dec;27(12):3481-3488. doi: 10.1016/j.sjbs.2020.09.061. Epub 2020 Oct 16.

Authors

Saad H Alotaibi¹, Hamada H Amer^{1

2}

Affiliations

¹ Department of Chemistry, University College of Turabah, Taif University, P.O. Box 11099, Taif 21944, Saudia Arabia.
² Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Egypt.

Abstract

New Nucleosides, analogues derived from 1, 3, 4-oxadiazole, arylidene analogues and α-aminophosphonate were prepared. Infrared (IR), elemental analysis and ¹HNMR elucidated nucleosides; arylidines and phosphonate derivatives. The prepared derivatives were purified and allowed to test against bacteria strains. Phosphonate derivative 12a showed the higher antibacterial against E. coli with inhibition zone 35 mm, P. aeruginosa with inhibition zone 30 and S. aureus with inhibition zone 22 while compounds 4, 6d, 9a, 9c and 12c showed moderate to weak activity against these bacteria species with inhibition zones ranged from 12 mm to 24 mm. The molecular docking studies was applied on compound 12a, which showed the binding at the active DNA Gyrase.

Keywords: 4-Nitrophenol; Antibacterial activity; Arylidene derivatives; Molecular docking; Nucleosides; α-aminophosphonate derivatives.