Measurement of Health-Related Quality of Life Among Colorectal Cancer Patients Using the Vietnamese Value Set of the EQ-5D-5L

Binh Thang Tran; Nhu Hiep Pham; Thanh Xuan Nguyen; Kui Son Choi; Dae Kyung Sohn; Sun-Young Kim; Jae Kyung Suh; Thuy Duyen Nguyen; Van Sang Phan; Dinh Trung Tran; The Thanh Nguyen; Thi Thanh Binh Nguyen; Minh Tu Nguyen; Jin-Kyoung Oh

doi:10.2147/PPA.S281500

Measurement of Health-Related Quality of Life Among Colorectal Cancer Patients Using the Vietnamese Value Set of the EQ-5D-5L

Patient Prefer Adherence. 2020 Dec 4:14:2427-2437. doi: 10.2147/PPA.S281500. eCollection 2020.

Authors

Binh Thang Tran^{1

2}, Nhu Hiep Pham³, Thanh Xuan Nguyen³, Kui Son Choi^{1

4}, Dae Kyung Sohn^{1

5}, Sun-Young Kim¹, Jae Kyung Suh⁶, Thuy Duyen Nguyen^{1

7}, Van Sang Phan², Dinh Trung Tran⁸, The Thanh Nguyen⁹, Thi Thanh Binh Nguyen¹⁰, Minh Tu Nguyen¹¹, Jin-Kyoung Oh^{1

12}

Affiliations

¹ Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Republic of Korea.
² Faculty of Public Health, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.
³ Department of Abdominal Emergency and Pediatric Surgery, Hue Central Hospital, Hue City, Vietnam.
⁴ National Cancer Control Institute; National Cancer Center, Goyang, Republic of Korea.
⁵ Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, South Korea.
⁶ Division of Healthcare Technology Assessment Research, National Evidence-Based Healthcare Collaborating Agency, Seoul, Korea.
⁷ Center for Population Health Sciences, Hanoi University of Public Health, Hanoi, Vietnam.
⁸ Faculty of Public Health, Da Nang University of Medical Technology and Pharmacy, Da Nang City, Vietnam.
⁹ Department of Endoscopy and Functional Exploration, Da Nang Oncology Hospital, Da Nang City, Vietnam.
¹⁰ Department of Pediatrics, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.
¹¹ Undergraduate Training Office, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.
¹² Division of Cancer Prevention & Early Detection, National Cancer Center, Goyang, Republic of Korea.

Abstract

Purpose: Health-related quality of life (HRQoL) is an important construct in clinical settings, and it is crucial that it should be properly measured. As the EuroQol-5-dimensions-5 levels (EQ-5D-5L) is more effective for such measurement than the 3-level model, data on economic models, clinical studies, and public health evaluations previously collected through the EQ-5D-3L need to be revaluated using the EQ-5D-5L. This study evaluated colorectal cancer (CRC) patients' HRQoL scores using the Vietnamese EQ-5D-5L value set.

Patients and methods: The cross-sectional study included CRC patients treated at a tertiary public hospital. HRQoL was assessed using the EQ-5D-5L, and HRQoL utility scores were calculated using the Vietnamese value set. Tobit regression examined factors associated with HRQoL.

Results: The analysis included 197 CRC patients. Ages ranged from 20 to 87 years (M = 57.64, SD = 13.5); 42.2% and 57.8% were diagnosed with cancer of the colon or rectum/anus, respectively. Mean EQ-5D-5L was 0.561 (range, -0.5115 to 1). Most participants experienced anxiety/depression (88%), followed by pain/discomfort (87%), mobility (71%), usual activity (69%), and self-care (67%). Advanced CRC stage (stage II: β -0.303, se 0.08; stage III: β -0.305, se 0.07; stage IV: β -0.456, se 0.07) and surgery (β -0.113, se 0.05) were negatively associated with EQ-5D-5L scores. Advanced education (high school: β 0.273, se 0.07); college/vocational: β 0.134se 0.05; university/higher: Coef 0.213, se 0.08;) and older age (age group 35-44: β 0.253, se 0.10; 45-54: β 0.327, se 0.09; 55-64: β 0.355 se 0.09; 65+ β 0.204, se 0.09) were positively associated with EQ-5D-5L scores.

Conclusion: Patients in advanced CRC stages or undergoing surgery experienced lower HRQoL and higher prevalence of anxiety/depression and pain/discomfort. Older age and high educational attainment predicted high HRQoL. This study provides information on CRC patients' health utility based on various patient characteristics, which can be used in future economic evaluations.

Keywords: EQ-5D-5L; HRQoL; Vietnam; colorectal cancer; utility.

Grants and funding

TDN received funding from the “International Cooperation & Education Program (#NCCRI·NCCI 52210-52211, 2019–2020)” of the National Cancer Center. The research project was partially supported by the National Cancer Center (grant no. 2010303).