Varying the Constant: Mechanisms of Fc-Mediated Immunity to Influenza Virus

Jenna M Kastenschmidt; Lisa E Wagar

doi:10.1016/j.chom.2020.11.009

Varying the Constant: Mechanisms of Fc-Mediated Immunity to Influenza Virus

Cell Host Microbe. 2020 Dec 9;28(6):769-770. doi: 10.1016/j.chom.2020.11.009.

Authors

Jenna M Kastenschmidt¹, Lisa E Wagar²

Affiliations

¹ Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California Irvine, Irvine, CA, USA.
² Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California Irvine, Irvine, CA, USA. Electronic address: lwagar@hs.uci.edu.

PMID: 33301713
DOI: 10.1016/j.chom.2020.11.009

Abstract

Antibodies are typically thought to mediate antiviral immunity by blocking host-cell infection. However, immunoglobulin G (IgG) can also stimulate antiviral responses through its constant region. A recent study in Nature (Bournazos et al., 2020) shows that modifying Fc binding affinities to better target FcɣRIIa enhances the influenza CD8 T cell response.

Publication types

Comment

MeSH terms

Antibodies, Viral
CD8-Positive T-Lymphocytes
Humans
Immunoglobulin Fc Fragments
Influenza, Human*
Orthomyxoviridae*

Substances

Antibodies, Viral
Immunoglobulin Fc Fragments