Puberty Is Associated with a Rising Hemoglobin A1c, Even in Youth with Normal Weight

Megan M Kelsey; Cameron Severn; Allison M Hilkin; Laura Pyle; Kristen J Nadeau; Philip S Zeitler

doi:10.1016/j.jpeds.2020.10.044

Puberty Is Associated with a Rising Hemoglobin A1c, Even in Youth with Normal Weight

J Pediatr. 2021 Mar:230:244-247. doi: 10.1016/j.jpeds.2020.10.044. Epub 2020 Oct 24.

Authors

Megan M Kelsey¹, Cameron Severn², Allison M Hilkin³, Laura Pyle², Kristen J Nadeau³, Philip S Zeitler³

Affiliations

¹ Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO. Electronic address: megan.kelsey@childrenscolorado.org.
² Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO; Department of Biostatistics, University of Colorado Denver School of Medicine, Aurora, CO.
³ Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO.

Abstract

Our objective was to explore the longitudinal trajectory of hemoglobin A1c (HbA1c) in well-characterized youth (n = 84) with normal weight and obesity during puberty. HbA1c rose from early puberty to Tanner stage 5, even in healthy, normal weight youth, revealing important implications for defining normal glycemia and prediabetes in adolescents.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Body Weight*
Child
Female
Glycated Hemoglobin / analysis*
Humans
Male
Pediatric Obesity / epidemiology*
Puberty / blood*
Reference Values

Substances

Glycated Hemoglobin A

Abstract

Publication types

MeSH terms

Substances

Grants and funding