Distinct associations of intraperitoneal and retroperitoneal visceral adipose tissues with metabolic syndrome and its components

Abstract

Background & aims: Metabolic syndrome (MS) is associated with adverse outcomes, and visceral adipose tissue (VAT) is associated with MS. Recently, VAT has been classified into intraperitoneal VAT (IVAT) and retroperitoneal VAT (RVAT). This study aimed to evaluate the association of IVAT and RVAT with the prevalence of MS or its components.

Methods: In our cross-sectional study, the prevalence of MS or its components was analyzed in 803 middle-aged Japanese participants. The cross-sectional area of the abdominal adipose tissue was evaluated from an unenhanced computed tomography scan at the third lumbar vertebra, and IVAT or RVAT was analyzed using a specialized software. The areas were normalized for the square of the participants' height in meters and described as the IVAT or RVAT area index.

Results: In age, sex, and BMI adjusted model, the IVAT, or RVAT area index was independently associated with the prevalence of MS. After simultaneous inclusion of IVAT, RVAT, and deep and superficial subcutaneous adipose tissue area indices for multivariate logistic regression analysis, the IVAT area index was found to be independently associated with the prevalence of MS (adjusted odds ratio [OR], 1.03; 95% confidence intervals [CI], 1.02-1.08) and its components, including waist circumference (OR, 1.07; 95% CI, 1.03-1.10), glucose (1.03; 1.01-1.05), triglycerides (1.03; 1.00-1.05), and high-density lipoprotein cholesterol (1.03; 1.00-1.05), whereas the RVAT area index was not. The RVAT area index was independently associated with the prevalence of component-blood pressure (1.06; 1.02-1.11), whereas the IVAT area index was not.

Conclusions: IVAT and RVAT are associated differently with the prevalence of MS and its components.

Keywords: Intraperitoneal visceral adipose tissue; Metabolic syndrome; Retroperitoneal visceral adipose tissue.