Post-treatment hypermutation in a recurrent diffuse glioma with H3.3 p.G34 Mutation

Neuropathol Appl Neurobiol. 2021 Apr;47(3):460-463. doi: 10.1111/nan.12679. Epub 2020 Dec 20.
No abstract available

Keywords: G34; H3F3A; Hypermutation; glioma; mismatch repair; molecular profiling.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antineoplastic Agents, Alkylating / adverse effects
  • Brain Neoplasms / genetics*
  • Brain Neoplasms / pathology
  • Brain Neoplasms / therapy
  • Chemoradiotherapy, Adjuvant
  • Drug Resistance, Neoplasm / genetics
  • Female
  • Glioma / genetics*
  • Glioma / pathology
  • Glioma / therapy
  • Histones / genetics*
  • Humans
  • Mutation / drug effects*
  • Neoplasm Recurrence, Local / genetics*
  • Neurosurgical Procedures
  • Temozolomide / adverse effects

Substances

  • Antineoplastic Agents, Alkylating
  • H3-3A protein, human
  • Histones
  • Temozolomide