Rh(iii)-Catalyzed acylation of heteroarenes with cyclobutenones via C-H/C-C bond activation

Yixin Cui; Dachang Bai; Bingxian Liu; Junbiao Chang; Xingwei Li

doi:10.1039/d0cc05965j

Rh(iii)-Catalyzed acylation of heteroarenes with cyclobutenones via C-H/C-C bond activation

Chem Commun (Camb). 2020 Dec 21;56(100):15631-15634. doi: 10.1039/d0cc05965j. Epub 2020 Dec 7.

Authors

Yixin Cui¹, Dachang Bai, Bingxian Liu, Junbiao Chang, Xingwei Li

Affiliation

¹ Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China. xwli@dicp.ac.cn baidachang@htu.edu.cn changjunbiao@zzu.edu.cn.

PMID: 33283807
DOI: 10.1039/d0cc05965j

Abstract

Rhodium(iii)-catalyzed C-H acylation of heteroarenes has been realized using cyclobutenones as an acylating reagent. This coupling proceeded via integration of C-H activation of heteroarenes and C-C cleavage of cyclobutenones. The reaction features excellent regio/chemoselectivity leading to versatile chalcones with exclusive E-selectivity.