In vivo intravascular photoacoustic imaging at a high speed of 100 frames per second

Zhihua Xie; Chengyou Shu; Daya Yang; Hao Chen; Chaobin Chen; Gang Dai; Kwok Ho Lam; Jinke Zhang; Xiatian Wang; Zonghai Sheng; Duyang Gao; Chengbo Liu; Liang Song; Xiaojing Gong

doi:10.1364/BOE.405792

In vivo intravascular photoacoustic imaging at a high speed of 100 frames per second

Biomed Opt Express. 2020 Oct 27;11(11):6721-6731. doi: 10.1364/BOE.405792. eCollection 2020 Nov 1.

Authors

Zhihua Xie^{1

2

3}, Chengyou Shu^{1

2

3}, Daya Yang^{4

5

3}, Hao Chen¹, Chaobin Chen¹, Gang Dai^{4

5}, Kwok Ho Lam⁶, Jinke Zhang^{1

2}, Xiatian Wang¹, Zonghai Sheng^{1

2}, Duyang Gao^{1

2}, Chengbo Liu^{1

2}, Liang Song^{1

2

7}, Xiaojing Gong^{1

2

8}

Affiliations

¹ Research Laboratory for Biomedical Optics and Molecular imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
² Research Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Guangdong Provincial Key Laboratory of Biomedical Optical Imaging Technology, CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Shenzhen 518055, China.
³ Equal contribution.
⁴ Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
⁵ Key Laboratory of Assisted Circulation, National Health Commission, Sun Yat-sen University, Guangzhou 510080, China.
⁶ Department of Electrical Engineering, The Hong Kong Polytechnic University, Hunghom, Hong Kong.
⁷ liang.song@siat.ac.cn.
⁸ xj.gong@siat.ac.cn.

Abstract

Intravascular photoacoustic (IVPA) imaging technology enables the visualization of pathological characteristics (such as inflammation activities, lipid deposition) of the artery wall. Blood flushing is a necessary step in improving the imaging quality in in vivo IVPA imaging. But the limited imaging speed of the systems stretches their flushing time, which is an important obstacle of their clinical translations. In this paper, we report an improvement in IVPA/IVUS imaging speed to 100 frames per second. The high-speed imaging is demonstrated in rabbit in vivo, visualizing the nanoparticles accumulated on abdominal aorta wall at the wavelength of 1064 nm, in real time display. Blood flushing in vivo improves the IVPA signal-noise-ratio by around 3.5 dB. This study offers a stable, efficient and easy-to-use tool for instantaneous disease visualization and disease diagnosis in research and forwards IVPA/IVUS imaging technology towards clinical translations.