Advances in Transposon Mutagenesis of Staphylococcus aureus: Insights into Pathogenesis and Antimicrobial Resistance

Trends Microbiol. 2021 Apr;29(4):282-285. doi: 10.1016/j.tim.2020.11.003. Epub 2020 Dec 3.

Abstract

Our capacity to investigate the biology of the major human and animal pathogen Staphylococcus aureus has been greatly enhanced by technological advances in transposon (Tn) mutagenesis. Here we provide a perspective on how these advances can further our understanding of pathogenesis and antibiotic resistance.

Keywords: Staphylococcus aureus; antimicrobial resistance; pathogenesis; transposon mutagenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • DNA Transposable Elements / genetics*
  • Drug Resistance, Bacterial / genetics*
  • Gene Library*
  • Host-Pathogen Interactions / genetics
  • Humans
  • Mutagenesis*
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / genetics*
  • Staphylococcus aureus / pathogenicity

Substances

  • Anti-Bacterial Agents
  • DNA Transposable Elements