Abstract
Our capacity to investigate the biology of the major human and animal pathogen Staphylococcus aureus has been greatly enhanced by technological advances in transposon (Tn) mutagenesis. Here we provide a perspective on how these advances can further our understanding of pathogenesis and antibiotic resistance.
Keywords:
Staphylococcus aureus; antimicrobial resistance; pathogenesis; transposon mutagenesis.
Copyright © 2020 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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DNA Transposable Elements / genetics*
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Drug Resistance, Bacterial / genetics*
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Gene Library*
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Host-Pathogen Interactions / genetics
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Humans
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Mutagenesis*
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / genetics*
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Staphylococcus aureus / pathogenicity
Substances
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Anti-Bacterial Agents
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DNA Transposable Elements