A biclonal case of chronic lymphocytic leukaemia with discordant mutational status of the immunoglobulin heavy chain variable region and bimodal CD49d expression

Br J Haematol. 2021 Feb;192(3):e77-e81. doi: 10.1111/bjh.17257. Epub 2020 Dec 5.
No abstract available

Keywords: CLL; IGHV; clonal architecture; trisomy 12; whole-exome sequencing.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged, 80 and over
  • Anemia / complications
  • Gene Expression Regulation, Leukemic
  • Humans
  • Immunoglobulin Heavy Chains / genetics*
  • Immunoglobulin Variable Region / genetics*
  • Integrin alpha4 / genetics*
  • Leukemia, Lymphocytic, Chronic, B-Cell / complications
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Lymphocytosis / complications
  • Male
  • Mutation

Substances

  • Immunoglobulin Heavy Chains
  • Immunoglobulin Variable Region
  • Integrin alpha4