Cell-based immunotherapy in gynecologic malignancies

Abstract

Purpose of review: To provide an update on cell-based immunotherapies in solid tumors particularly in gynecological cancers.

Recent findings: Recent clinical trial results demonstrate safety and tolerability of different cell therapies in gynecological cancers. Novel approaches, such as harnessing the cells of the innate immune system are also under investigation in a phase I trial.

Summary: Cell-based therapies are gaining widespread attention as evidenced by the increasing number of clinical trials encompassing both, innate and adaptive cells to target gynecological cancers. A majority of these therapeutic approaches are well tolerated and show promising results in early trials.

Trial registration: ClinicalTrials.gov NCT02948426.