Primary Hyperparathyroidism in a Quarter Horse Mare Associated With a Chief Cell Adenoma

J Equine Vet Sci. 2020 Dec:95:103302. doi: 10.1016/j.jevs.2020.103302. Epub 2020 Oct 17.

Abstract

Primary hyperparathyroidism is rare in large animal species, and little is known regarding its pathophysiology, endocrine and electrolyte derangements, diagnosis, medical management, and prognosis. This report describes the clinicopathologic diagnosis of a parathyroid (PT) gland chief cell adenoma in a 12-year-old Quarter Horse mare, including PT hormone (PTH) and electrolyte disarrangements associated with the neoplasia, the surgical removal of the adenoma, and medical management of the case. This report also describes for the first time the use PTH immunohistochemistry to confirm the nature of this neoplasia in a horse.

Keywords: Equine; Hypercalcemia; Hypocalcemia; Hypophosphatemia; Parathyroid hormone.

Publication types

  • Case Reports

MeSH terms

  • Adenoma* / complications
  • Adenoma* / veterinary
  • Animals
  • Female
  • Horse Diseases* / diagnosis
  • Horses
  • Hypercalcemia* / veterinary
  • Hyperparathyroidism, Primary* / diagnosis
  • Hyperparathyroidism, Primary* / veterinary
  • Parathyroid Hormone
  • Parathyroid Neoplasms* / complications
  • Parathyroid Neoplasms* / veterinary

Substances

  • Parathyroid Hormone