Metal-Free Synthesis and Photophysical Properties of 1,2,4-Triarylpyrroles

Dan Chang; Jinjin Chen; Yong Liu; Huawen Huang; Anjun Qin; Guo-Jun Deng

doi:10.1021/acs.joc.0c01788

Metal-Free Synthesis and Photophysical Properties of 1,2,4-Triarylpyrroles

J Org Chem. 2021 Jan 1;86(1):110-127. doi: 10.1021/acs.joc.0c01788. Epub 2020 Dec 2.

Authors

Dan Chang¹, Jinjin Chen¹, Yong Liu², Huawen Huang¹, Anjun Qin², Guo-Jun Deng^{1

2}

Affiliations

¹ Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China.
² Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China.

PMID: 33263405
DOI: 10.1021/acs.joc.0c01788

Abstract

A three-component reaction has been developed for the construction of multiaryl-substituted pyrrole derivatives from arylketones, amines, and nitrovinylarenes under metal-free conditions. Hence, homologous 1,2,4-triaryl-substituted pyrrole products were obtained in good to high yields. Furthermore, 2,3,5-triaryl-substituted pyrroles were selectively formed in the absence of nitrovinylarenes. The photophysical properties of some pyrrole products have been investigated to show good aggregation-induced emission (AIE) activity.