A Sweet Approach to Heat Up Cancer Response to Immunotherapy

Oliver M T Pearce; Heinz Läubli

doi:10.1158/2159-8290.CD-20-1355

A Sweet Approach to Heat Up Cancer Response to Immunotherapy

Cancer Discov. 2020 Dec;10(12):1789-1790. doi: 10.1158/2159-8290.CD-20-1355.

Authors

Oliver M T Pearce¹, Heinz Läubli²

Affiliations

¹ Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom. o.pearce@qmul.ac.uk.
² Department of Biomedicine, University of Basel and Division of Oncology, University Hospital Basel, Basel, Switzerland.

PMID: 33262181
DOI: 10.1158/2159-8290.CD-20-1355

Abstract

Song and colleagues describe how N-glycans stabilize expression of checkpoint molecule B7-H4 that suppresses T-cell function. Inhibiting N-glycan stabilization of B7-H4 generates an immune hot cancer that is more responsive to combination therapies.See related article by Song et al., p. 1872.

Publication types

Comment

MeSH terms

Breast Neoplasms*
Glycosylation
Humans
Immunotherapy
T-Lymphocytes / metabolism
V-Set Domain-Containing T-Cell Activation Inhibitor 1* / metabolism

Substances

V-Set Domain-Containing T-Cell Activation Inhibitor 1