Advances in the Chemical and Biological Characterization of Amaryllidaceae Alkaloids and Natural Analogues Isolated in the Last Decade

Molecules. 2020 Nov 29;25(23):5621. doi: 10.3390/molecules25235621.

Abstract

Amaryllidaceae are bulbous wild and cultivated plants well known for their beautiful flowers and pharmaceutical applications, essentially due to the alkaloids and flavonoids content. Hundreds of alkaloids have been isolated until now and several scientific publications reported their sources, chemical structures, and biological activities. During the last decade, some unstudied Amaryllidaceae plants were the object of in-depth investigations to isolate and chemically and biologically characterize new and already known alkaloids as well as some analogues. This review describes the isolation and chemical and biological characterization of the Amaryllidaceae alkaloids, and their analogues obtained in the last decade, focusing the discussion on the new ones.

Keywords: Amaryllidaceae; alkaloids; last decade; natural analogues.

Publication types

  • Review

MeSH terms

  • Amaryllidaceae / chemistry*
  • Amaryllidaceae Alkaloids / chemistry*
  • Amaryllidaceae Alkaloids / isolation & purification
  • Amaryllidaceae Alkaloids / pharmacology*
  • Medicine, Traditional
  • Phytotherapy
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Roots / chemistry
  • Structure-Activity Relationship

Substances

  • Amaryllidaceae Alkaloids
  • Plant Extracts