Concentration-Dependent Interactions of Amphiphilic PiB Derivative Metal Complexes with Amyloid Peptides Aβ and Amylin*

Saida Majdoub; Zoltán Garda; Alexandre C Oliveira; Inga Relich; Agnès Pallier; Sara Lacerda; Christelle Hureau; Carlos F G C Geraldes; Jean-François Morfin; Éva Tóth

doi:10.1002/chem.202004825

Concentration-Dependent Interactions of Amphiphilic PiB Derivative Metal Complexes with Amyloid Peptides Aβ and Amylin*

Chemistry. 2021 Jan 26;27(6):1864. doi: 10.1002/chem.202004825. Epub 2020 Dec 1.

Authors

Affiliations

¹ Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans, rue Charles Sadron, 45071, Orléans, France.
² Department of Physical Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, 4032, Debrecen, Hungary.
³ Department of Chemistry, University of Coimbra, Coimbra Chemistry Centre (CQC), 3004-535, Coimbra, Portugal.
⁴ LCC-CNRS, Université de Toulouse, CNRS, Toulouse, France.
⁵ Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-393, Coimbra, Portugal.
⁶ CIBIT/ICNAS-Instituto de Ciências Nucleares Aplicadas à Saúde, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal.

PMID: 33258526
DOI: 10.1002/chem.202004825

Abstract

Invited for the cover of this issue are Jean-François Morfin and Éva Tóth at the CNRS in Orléans, and their collaborators from University of Debrecen, University of Coimbra and Université de Toulouse. The image depicts that when an amphiphilic compound is intravenously injected, monomer, pre-micellar and micellar forms can co-exist in the blood and have different affinities for amyloid peptides. Read the full text of the article at 10.1002/chem.202004000.

MeSH terms

Amyloid
Coordination Complexes / chemistry*
Islet Amyloid Polypeptide

Substances

Amyloid
Coordination Complexes
Islet Amyloid Polypeptide