This is a comprehensive review of the principles and applications of adaptive optics (AO) in ophthalmology. It has been combined with flood illumination ophthalmoscopy, scanning laser ophthalmoscopy, as well as optical coherence tomography to image photoreceptors, retinal pigment epithelium (RPE), retinal ganglion cells, lamina cribrosa and the retinal vasculature. In this review, we highlight the clinical studies that have utilised AO to understand disease mechanisms. However, there are some limitations to using AO in a clinical setting including the cost of running an AO imaging service, the time needed to scan patients, the lack of normative databases and the very small size of area imaged. However, it is undoubtedly an exceptional research tool that enables visualisation of the retina at a cellular level.
摘要: 本文对自适应光学 (AO) 成像系用在眼科中的应用和原理做出了全面的综述。AO已与检眼镜、扫描激光检眼镜以及光学相干光断层扫描等检查相结合, 用于感光细胞、视网膜色素上皮、视网膜神经节细胞、筛板和视网膜血管系统的成像。在这篇综述中, 我们着重介绍了利用AO探索疾病机理的临床研究。然而, 临床使用AO也存在着一些局限性, 包括AO成像操作的成本、扫描患者所需的时间、缺乏规范的数据库以及成像区域的尺寸非常小等缺点。但是, AO可以在细胞水平上将视网膜可视化, 所以它无疑是一个出色的研究工具。.