Loss of Phosphatase and Tensin Homolog Promotes Cardiomyocyte Proliferation and Cardiac Repair After Myocardial Infarction

Circulation. 2020 Dec;142(22):2196-2199. doi: 10.1161/CIRCULATIONAHA.120.046372. Epub 2020 Nov 30.

Tian Liang^#^{1

2}, Feng Gao^#^{1

2}, Jun Jiang^#¹, Yao Wei Lu³, Feng Zhang^{1

2}, Yingchao Wang⁴, Ning Liu^{1

2}, Xuyang Fu², Xiaoxuan Dong², Jianqiu Pei⁵, Douglas B Cowan³, Xinyang Hu¹, Jian'an Wang¹, Da-Zhi Wang^{3

6}, Jinghai Chen^{1

2}

¹ Department of Cardiology, Provincial Key Lab of Cardiovascular Research, Second Affiliated Hospital (T.L., F.G., J.J., F.Z., N.L., X.F., X.D., X.H., J.W., J.C.), Hangzhou, China.
² Institute of Translational Medicine (T.L., F.G., F.Z., N.L., X.F., X.D., J.C.), Hangzhou, China.
³ Department of Cardiology, Boston Children's Hospital, Harvard Medical School, MA (Y.W.L., D.B.C., D-Z.W.).
⁴ Zhejiang University School of Medicine, and Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University (Y.W.), Hangzhou, China.
⁵ State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (J.P.).
⁶ Harvard Stem Cell Institute, Harvard University, Cambridge, MA (D-Z-W.).

^# Contributed equally.

No abstract available

Keywords: PTEN; cardiomyocyte proliferation; myocardial infarction; regeneration.

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