In-situ biotransformation of nitric oxide by functionalized surfaces of cardiovascular stents

Meng Qian; Qi Liu; Yan Wei; Zhikun Guo; Qiang Zhao

doi:10.1016/j.bioactmat.2020.10.030

In-situ biotransformation of nitric oxide by functionalized surfaces of cardiovascular stents

Bioact Mater. 2020 Nov 11;6(5):1464-1467. doi: 10.1016/j.bioactmat.2020.10.030. eCollection 2021 May.

Authors

Meng Qian^{1

2}, Qi Liu^{1

2}, Yan Wei¹, Zhikun Guo^{1

3}, Qiang Zhao^{1

2}

Affiliations

¹ Zhengzhou Cardiovascular Hospital and 7th People's Hospital of Zhengzhou, Zhengzhou, Henan Province, China.
² State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University, Tianjin 300071, China.
³ Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, China.

Abstract

Cardiovascular diseases (CVDs) are among the leading causes of mortality and morbidity worldwide. Nitric oxide (NO) is a signalling molecule that plays a vital role in protecting and regulating cardiovascular function and homeostasis. Despite several successful outcomes of exogenous supplementation of NO for cardiovascular disease therapy, a great challenge lies in controlled and long-term delivery due to the short half-life and instability of NO. Recently, increasing attention has been paid to the in situ conversion of endogenous NO donors catalysed by functional surfaces. Based on bioinspired and biomimicking strategies, a series of surface functionalization methods for cardiovascular stents has been successfully developed. By further combining NO catalysis with other biofunctionalities, improved endothelium healing and long-term patency can be anticipated.