Developing Insulin Delivery Devices with Glucose Responsiveness

Zejun Wang; Jinqiang Wang; Anna R Kahkoska; John B Buse; Zhen Gu

doi:10.1016/j.tips.2020.11.002

Developing Insulin Delivery Devices with Glucose Responsiveness

Trends Pharmacol Sci. 2021 Jan;42(1):31-44. doi: 10.1016/j.tips.2020.11.002. Epub 2020 Nov 26.

Authors

Zejun Wang¹, Jinqiang Wang², Anna R Kahkoska³, John B Buse⁴, Zhen Gu⁵

Affiliations

¹ Department of Bioengineering, University of California, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA.
² Department of Bioengineering, University of California, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA; College of Pharmaceutical Sciences, Zhejiang University, 310058 Hangzhou, China.
³ Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
⁴ Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: john_buse@med.unc.edu.
⁵ Department of Bioengineering, University of California, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA; College of Pharmaceutical Sciences, Zhejiang University, 310058 Hangzhou, China; California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA. Electronic address: guzhen@zju.edu.cn.

Abstract

Individuals with type 1 and advanced type 2 diabetes require daily insulin therapy to maintain blood glucose levels in normoglycemic ranges to prevent associated morbidity and mortality. Optimal insulin delivery should offer both precise dosing in response to real-time blood glucose levels as well as a feasible and low-burden administration route to promote long-term adherence. A series of glucose-responsive insulin delivery mechanisms and devices have been reported to increase patient compliance while mitigating the risk of hypoglycemia. This review discusses currently available insulin delivery devices, overviews recent developments towards the generation of glucose-responsive delivery systems, and provides commentary on the opportunities and barriers ahead regarding the integration and translation of current glucose-responsive insulin delivery designs.

Keywords: diabetes treatment; drug delivery; glucose-responsive; insulin administration device.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Blood Glucose
Diabetes Mellitus, Type 2* / drug therapy
Glucose*
Humans
Hypoglycemic Agents
Insulin

Substances

Blood Glucose
Hypoglycemic Agents
Insulin
Glucose

Abstract

Publication types

MeSH terms

Substances

Grants and funding