Preparations and antioxidant activities of sesamol and it's derivatives

Shiyang Zhou; Huiying Zou; Gangliang Huang; Guangying Chen

doi:10.1016/j.bmcl.2020.127716

Preparations and antioxidant activities of sesamol and it's derivatives

Bioorg Med Chem Lett. 2021 Jan 1:31:127716. doi: 10.1016/j.bmcl.2020.127716. Epub 2020 Nov 26.

Authors

Shiyang Zhou¹, Huiying Zou², Gangliang Huang³, Guangying Chen⁴

Affiliations

¹ College of Chemistry and Chemical Engineering, Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China; Active Carbohydrate Research Institute, Chongqing Key Laboratory of Inorganic Functional Materials, College of Chemistry, Chongqing Normal University, Chongqing 401331, China.
² College of Chemistry and Chemical Engineering, Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China.
³ Active Carbohydrate Research Institute, Chongqing Key Laboratory of Inorganic Functional Materials, College of Chemistry, Chongqing Normal University, Chongqing 401331, China. Electronic address: huangdoctor226@163.com.
⁴ College of Chemistry and Chemical Engineering, Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China. Electronic address: chgying123@163.com.

PMID: 33249134
DOI: 10.1016/j.bmcl.2020.127716

Abstract

Antioxidants is a kind of substances that can effectively inhibit the oxidation reaction of free radicals. There are many chemical components with antioxidant activity in natural products. Sesamol is one of the natural products with antioxidant activity, and it is often used as an antioxidant in food, medicine and other fields. In the present study, sesame was used as the extraction raw material for the extraction and separated of sesamol with antioxidant activity. On this basis, a total 10 of sesamol derivatives were synthesized by two steps reaction with sesamol as starting material. The antioxidant activity of these sesamol derivatives were tested, and the test results showed that these sesamol derivatives had a good antioxidant activity, among them, compound 4d had the best antioxidant activity. Sesamol derivatives can be used as an antioxidant in food, medicine and other fields and it needs a further study.

Keywords: Antioxidant; Natural product; Sesamol derivatives.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants / chemical synthesis
Antioxidants / chemistry
Antioxidants / pharmacology*
Benzodioxoles / chemical synthesis
Benzodioxoles / chemistry
Benzodioxoles / pharmacology*
Biological Products / chemical synthesis
Biological Products / chemistry
Biological Products / pharmacology*
Dose-Response Relationship, Drug
Hydroxyl Radical / antagonists & inhibitors*
Molecular Structure
Phenols / chemical synthesis
Phenols / chemistry
Phenols / pharmacology*
Structure-Activity Relationship
Superoxides / antagonists & inhibitors*

Substances

Antioxidants
Benzodioxoles
Biological Products
Phenols
Superoxides
Hydroxyl Radical
sesamol