Cytomegalovirus-Specific Immunoglobulin G Is Associated With Chronic Lung Disease in Children and Adolescents from Sub-Saharan Africa Living With Perinatal Human Immunodeficiency Virus

Clin Infect Dis. 2021 Jul 1;73(1):e264-e266. doi: 10.1093/cid/ciaa1757.

Abstract

In a cross-sectional study of 296 children and adolescents from Zimbabwe living with perinatal human immunodeficiency virus, individuals with the top tertile of cytomegalovirus-specific immunoglobulin G titer had an increased odds of chronic lung disease (odds ratio, 3.33; 95% confidence interval, 1.37-8.85; P = .010).

Keywords: HIV; cytomegalovirus; immunoglobulin G; lung disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Africa South of the Sahara / epidemiology
  • Child
  • Cross-Sectional Studies
  • Cytomegalovirus
  • Female
  • HIV
  • HIV Infections* / complications
  • HIV Infections* / epidemiology
  • Humans
  • Immunoglobulin G
  • Lung Diseases* / epidemiology
  • Pregnancy
  • Zimbabwe

Substances

  • Immunoglobulin G