BBOX1 promotes triple-negative breast cancer progression by controlling IP3R3 stability

Chengheng Liao; Qing Zhang

doi:10.1080/23723556.2020.1813526

BBOX1 promotes triple-negative breast cancer progression by controlling IP3R3 stability

Mol Cell Oncol. 2020 Sep 6;7(6):1813526. doi: 10.1080/23723556.2020.1813526. eCollection 2020.

Authors

Chengheng Liao¹, Qing Zhang¹

Affiliation

¹ Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Abstract

Limited therapeutic options impede the clinical outcome of triple-negative breast cancer (TNBC). Our recent study uncovered a novel signaling pathway implicating gamma-butyrobetaine hydroxylase 1 (BBOX1) in the control of cell growth in TNBC, via inositol 1, 4, 5-trisphosphate receptor type 3 (IP3R3) mediated calcium signaling which is essential for cellular energy metabolism.

Keywords: 2-OG dependent enzyme; TNBC; therapeutic target.

Grants and funding

This work was supported by Cancer Prevention and Research Institute of Texas (Q. Zhang, CPRIT, RR190058).