From Radical to Partial Nephrectomy in the Setting of Solitary Functioning Kidney: Neoadjuvant Treatment of Renal Cell Carcinoma

David D Watson; Nicole M Farha; K James Kallail; Shaker Dakhil; A J Farha

From Radical to Partial Nephrectomy in the Setting of Solitary Functioning Kidney: Neoadjuvant Treatment of Renal Cell Carcinoma

Rev Urol. 2020;22(3):126-129.

Authors

David D Watson¹, Nicole M Farha¹, K James Kallail², Shaker Dakhil³, A J Farha⁴

Affiliations

¹ University of Kansas School of Medicine Wichita, KS.
² Department of Research, University of Kansas School of Medicine Wichita, KS.
³ Cancer Center of Kansas Wichita, KS.
⁴ Wichita Urology Group Wichita, KS.

PMID: 33239972
PMCID: PMC7672501

Abstract

Immunotherapy has revolutionized the treatment of metastatic renal cell carcinoma (RCC). This case evaluates the use of neoadjuvant immunotherapy for localized RCC in a patient with solitary functioning kidney. A retrospective chart review was conducted between September 2019 and January 2020 on a single patient. Before treatment, the tumor was 7 cm × 8 cm × 8.5 cm. The patient trialed nivolumab + ipilimumab then cabozantinib. The tumor shrunk to 6.3 cm × 5.5 cm and was removed via partial nephrectomy. This case demonstrates the efficacy of immunotherapy in neoadjuvant treatment of RCC. Expansion of guidelines could allow for patients with RCC to undergo partial nephrectomy.

Keywords: Immunotherapy; Neoadjuvant immunotherapy; Renal cell carcinoma; Solitary kidney.

Publication types

Case Reports