Familial DNA analysis and criminal investigation: Usage, downsides and privacy concerns

Forensic Sci Int. 2021 Jan:318:110576. doi: 10.1016/j.forsciint.2020.110576. Epub 2020 Nov 4.

Abstract

Since the discovery of Deoxyribonucleic acid (DNA) capability in forensic investigation, it has been an important part of the criminal justice system. In most criminal cases DNA profile originating from evidence sample collected from the crime scene is compared with the DNA profile from the reference sample. However, when a reference sample is not available for comparison, familial DNA analysis can provide important investigation leads in a criminal investigation process by identifying an individual. Moreover, this analysis is also proving effective in the identification of ethnicity and ancestry of an individual. A number of different methodologies and software are being used for familial DNA analysis. This review describes the importance of familial DNA analysis, methodologies used for familial DNA searching and identification, and its advantages in forensic. Moreover, ethical, legal and social issues associated with familial DNA analysis have also been discussed along with future directions for the proper implementation of this technology.

Keywords: Ancestry; Criminal investigation; Ethical issues; Familial DNA; Genealogy.

Publication types

  • Review

MeSH terms

  • Chromosomes, Human, Y
  • DNA Fingerprinting* / ethics
  • DNA Fingerprinting* / legislation & jurisprudence
  • DNA, Mitochondrial
  • Databases, Genetic*
  • Forensic Genetics / ethics
  • Forensic Genetics / legislation & jurisprudence
  • Genetic Privacy
  • Genotype
  • Humans
  • Microsatellite Repeats
  • Pedigree*
  • Polymorphism, Single Nucleotide
  • Racial Groups / genetics

Substances

  • DNA, Mitochondrial