On the consensus nomenclature rules for radiopharmaceutical chemistry - Reconsideration of radiochemical conversion

Matthias M Herth; Simon Ametamey; Dmitrii Antuganov; Andreas Bauman; Mathias Berndt; Allen F Brooks; Guy Bormans; Yearn Seong Choe; Nic Gillings; Urs O Häfeli; Michelle L James; Klaus Kopka; Vasko Kramer; Raisa Krasikova; Jacob Madsen; Linjing Mu; Bernd Neumaier; Markus Piel; Frank Rösch; Tobias Ross; Roger Schibli; Peter J H Scott; Vladimir Shalgunov; Neil Vasdev; Wolfgang Wadsak; Brian M Zeglis

doi:10.1016/j.nucmedbio.2020.11.003

On the consensus nomenclature rules for radiopharmaceutical chemistry - Reconsideration of radiochemical conversion

Nucl Med Biol. 2021 Feb:93:19-21. doi: 10.1016/j.nucmedbio.2020.11.003. Epub 2020 Nov 18.

Authors

Matthias M Herth¹, Simon Ametamey², Dmitrii Antuganov³, Andreas Bauman⁴, Mathias Berndt⁵, Allen F Brooks⁶, Guy Bormans⁷, Yearn Seong Choe⁸, Nic Gillings⁹, Urs O Häfeli¹⁰, Michelle L James¹¹, Klaus Kopka¹², Vasko Kramer¹³, Raisa Krasikova¹⁴, Jacob Madsen⁹, Linjing Mu², Bernd Neumaier¹⁵, Markus Piel¹⁶, Frank Rösch¹⁶, Tobias Ross¹⁷, Roger Schibli², Peter J H Scott⁶, Vladimir Shalgunov¹⁸, Neil Vasdev¹⁹, Wolfgang Wadsak²⁰, Brian M Zeglis²¹

Affiliations

¹ Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 160, 2100 Copenhagen, Denmark; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark. Electronic address: matthias.herth@sund.ku.dk.
² Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, 8093 Zürich, Switzerland.
³ Almazov Northwest Federal Medical Research Center, Ministry of Health of the Russian Federation, ul. Akkuratova 2, St. Petersburg 197341, Russia.
⁴ Clinic of Radiology and Nuclear Medicine, University of Basel Hospital, Petersgraben 4, CH-4031 Basel, Switzerland.
⁵ Life Molecular Imaging GmbH, Tegeler Str. 6-7, D-13353 Berlin, Germany.
⁶ Department of Radiology, University of Michigan Medical School, 1301 Catherine St, Ann Arbor, MI 48109, USA.
⁷ Laboratory for Radiopharmaceutical Research, KU Leuven, Herestraat 49, box 821, 3000 Leuven, Belgium.
⁸ Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea.
⁹ Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
¹⁰ Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.
¹¹ Department of Radiology and Department of Neurology and Neurological Sciences Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, 1201 Welch Road, P-206, Stanford, CA 94305, USA.
¹² Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Bautzner Landstraße 400, D-01328 Dresden, Germany.
¹³ Positronpharma SA, Providencia, 7500921 Santiago, Chile.
¹⁴ N.P. Bechtereva Institute of Human Brain, Russian Academy of Science, Laboratory of Radiochemistry, 9 Ak. Pavlova St., 197376 St. Petersburg, Russia.
¹⁵ Institute of Neuroscience and Medicine, Forschungszentrum Jülich, D-52425 Jülich, Germany.
¹⁶ Department of Chemistry, Johannes Gutenberg-Universität Mainz, Fritz-Strassmann-Weg 2, D-55128 Mainz, Germany.
¹⁷ Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Straße 1, D-30625 Hannover, Germany.
¹⁸ Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 160, 2100 Copenhagen, Denmark.
¹⁹ Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health & Department of Psychiatry, University of Toronto, 250 College St., Toronto M5T-1R8, ON, Canada.
²⁰ Department of Biomedical Imaging und Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
²¹ Department of Chemistry, Hunter College of the City University of New York, New York, NY, USA; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

PMID: 33232876
DOI: 10.1016/j.nucmedbio.2020.11.003

Abstract

Radiochemical conversion is an important term to be included in the "Consensus nomenclature rules for radiopharmaceutical chemistry". Radiochemical conversion should be used to define reaction efficiency by measuring the transformation of components in a crude reaction mixture at a given time, whereas radiochemical yield is better suited to define the efficiency of an entire reaction process including, for example, separation, isolation, filtration, and formulation.

Keywords: Consensus guidelines; Nomenclature; Nuclear chemistry; Radiochemical conversion; Radiochemical yield; Radiochemistry; Radiopharmaceutical sciences; Terminology.

Publication types

Letter
Comment

MeSH terms

Consensus
Radiochemistry
Radiopharmaceuticals*

Substances

Radiopharmaceuticals