Intestinal Inflammation is Linked to Hypoacetylation of Histone 3 Lysine 27 and can be Reversed by Valproic Acid Treatment in Inflammatory Bowel Disease Patients

Cell Mol Gastroenterol Hepatol. 2021;11(3):889-891.e6. doi: 10.1016/j.jcmgh.2020.11.009. Epub 2020 Nov 21.
No abstract available

Publication types

  • Letter
  • Observational Study

MeSH terms

  • Acetylation / drug effects
  • Adolescent
  • Adult
  • Aged
  • Animals
  • Biopsy
  • Cohort Studies
  • Colitis, Ulcerative / chemically induced
  • Colitis, Ulcerative / drug therapy*
  • Colitis, Ulcerative / genetics
  • Colitis, Ulcerative / pathology
  • Colon / drug effects
  • Colon / immunology
  • Colon / pathology
  • Crohn Disease / drug therapy*
  • Crohn Disease / genetics
  • Crohn Disease / pathology
  • Dextran Sulfate / administration & dosage
  • Dextran Sulfate / toxicity
  • Disease Models, Animal
  • Epigenesis, Genetic / drug effects
  • Female
  • Histone Deacetylase Inhibitors / pharmacology
  • Histone Deacetylase Inhibitors / therapeutic use*
  • Histones / metabolism*
  • Humans
  • Intestinal Mucosa / drug effects
  • Intestinal Mucosa / immunology
  • Intestinal Mucosa / pathology
  • Male
  • Mice
  • Middle Aged
  • Valproic Acid / pharmacology
  • Valproic Acid / therapeutic use*
  • Young Adult

Substances

  • Histone Deacetylase Inhibitors
  • Histones
  • Valproic Acid
  • Dextran Sulfate