Nanoenzymes in disease diagnosis and therapy

Chem Commun (Camb). 2020 Dec 25;56(99):15513-15524. doi: 10.1039/d0cc05427e. Epub 2020 Nov 24.

Abstract

Nanoenzymes, as a new generation of artificial enzymes with highly effective enzyme-like properties, have come into focus and have achieved great progress. Considering the enormous potential of nanoenzymes in the field of disease diagnosis and treatment, such as biological detection, anti-inflammatory, anti-oxidative damage and cancer treatments, etc., we firstly summarize the wide range of bio-applications of different nanoenzymes in these fields. In this review, we discuss the factors influencing the properties of nanoenzymes such as pH and temperature, surface modification and doping of other elements. In addition, we introduce five kinds of nanoenzymes and their bio-applications in various diseases. The current review will make researchers better understand the current state of the development of nanoenzymes and may be beneficial for new breakthroughs.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Bacterial Infections / diagnosis
  • Bacterial Infections / drug therapy
  • Humans
  • Hydrogen-Ion Concentration
  • Nanostructures / chemistry*
  • Neoplasms* / diagnosis
  • Neoplasms* / drug therapy
  • Temperature

Substances

  • Anti-Inflammatory Agents, Non-Steroidal