Radiosurgery for Glioblastoma

Adomas Bunevicius; Jason P Sheehan

doi:10.1016/j.nec.2020.08.007

Radiosurgery for Glioblastoma

Neurosurg Clin N Am. 2021 Jan;32(1):117-128. doi: 10.1016/j.nec.2020.08.007. Epub 2020 Nov 5.

Authors

Adomas Bunevicius¹, Jason P Sheehan²

Affiliations

¹ Department of Neurosurgery, University of Virginia Health System, Charlottesville, VA 22908, USA.
² Department of Neurosurgery, University of Virginia Health System, Charlottesville, VA 22908, USA. Electronic address: jps2f@hscmail.mcc.virginia.edu.

PMID: 33223020
DOI: 10.1016/j.nec.2020.08.007

Abstract

Glioblastoma (GBM) is infiltrative neoplasm with limited treatment options and poor overall survival. Stereotactic radiosurgery (SRS) allows spatially precise and conformal delivery of high doses of radiation. Salvage SRS for locally recurrent GBM was shown to improve patient survival and have more favorable safety profile than repeated surgical resection. Boost SRS after fractionated radiation therapy is sometimes attempted; however, Radiation Therapy Oncology Group 93-05 randomized clinical trial did not demonstrate benefits of upfront SRS that was administered before fractionated radiation. Administration of bevacizumab with SRS is associated with improved survival and can allow SRS dose escalation.

Keywords: Gamma knife radiosurgery; Glioblastoma; Prognosis; Stereotactic radiosurgery; Survival.

Publication types

Review

MeSH terms

Brain Neoplasms / radiotherapy*
Glioblastoma / radiotherapy*
Humans
Neoplasm Recurrence, Local / radiotherapy
Radiosurgery*
Treatment Outcome