Stereotactic Laser Ablation of Glioblastoma

Matthew M Grabowski; Balint Otvos; Alireza M Mohammadi

doi:10.1016/j.nec.2020.08.006

Stereotactic Laser Ablation of Glioblastoma

Neurosurg Clin N Am. 2021 Jan;32(1):105-115. doi: 10.1016/j.nec.2020.08.006. Epub 2020 Nov 5.

Authors

Matthew M Grabowski¹, Balint Otvos¹, Alireza M Mohammadi²

Affiliations

¹ Department of Neurosurgery, Rose Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA.
² Department of Neurological Surgery, Cleveland Clinic Lerner College of Medicine at CWRU, Rose Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic, CA-51, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: MOHAMMA3@ccf.org.

PMID: 33223019
DOI: 10.1016/j.nec.2020.08.006

Abstract

The previous decade has seen an expansion in the use of laser interstitial thermal therapy (LITT) for a variety of pathologies. LITT has been used to treat both newly diagnosed and recurrent glioblastoma (GBM), especially in deep-seated, difficult-to-access lesions where open resection is otherwise infeasible or in patients who would not tolerate craniotomy. This review aims to describe the current state of the technology and operative technique, as well as summarize the outcomes data and future research regarding LITT as a treatment of GBM.

Keywords: GBM; Glioblastoma; LITT; Laser interstitial thermal therapy; SLA; Stereotactic laser ablation.

Publication types

Review

MeSH terms

Brain Neoplasms / surgery*
Glioblastoma / surgery*
Humans
Laser Therapy / methods*
Minimally Invasive Surgical Procedures / methods
Stereotaxic Techniques
Treatment Outcome