Perineal desquamation: An early sign of the Kawasaki disease phenotype of MIS-C

Pediatr Dermatol. 2021 Jan;38(1):253-256. doi: 10.1111/pde.14462. Epub 2020 Nov 22.

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a syndrome associated with coronavirus disease 2019. Various phenotypes of MIS-C have been described including Kawasaki disease (KD). Although perineal desquamation is a known early sign of KD, to our knowledge, this rash has not yet been described in the KD phenotype of MIS-C. In this article, we report two patients in whom perineal desquamation was an early clue for the KD phenotype of MIS-C.

Keywords: COVID-19; Kawasaki disease; MIS-C; Multisystem Inflammatory Syndrome in Children; coronavirus disease 2019; perineal desquamation; skin of color.

Publication types

  • Case Reports

MeSH terms

  • COVID-19 / diagnosis*
  • Child, Preschool
  • Diagnosis, Differential
  • Humans
  • Infant
  • Male
  • Mucocutaneous Lymph Node Syndrome / diagnosis*
  • Perineum / pathology*
  • Phenotype
  • Skin Diseases, Infectious / pathology*
  • Systemic Inflammatory Response Syndrome / diagnosis*

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related