Total-Body PET Imaging of Musculoskeletal Disorders

Abhijit J Chaudhari; William Y Raynor; Ali Gholamrezanezhad; Thomas J Werner; Chamith S Rajapakse; Abass Alavi

doi:10.1016/j.cpet.2020.09.012

Total-Body PET Imaging of Musculoskeletal Disorders

PET Clin. 2021 Jan;16(1):99-117. doi: 10.1016/j.cpet.2020.09.012.

Authors

Abhijit J Chaudhari¹, William Y Raynor², Ali Gholamrezanezhad³, Thomas J Werner⁴, Chamith S Rajapakse⁴, Abass Alavi⁴

Affiliations

¹ Department of Radiology, University of California Davis, 4860 Y Street, Sacramento, CA 95825, USA. Electronic address: ajchaudhari@ucdavis.edu.
² Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Drexel University College of Medicine, 2900 West Queen Lane, Philadelphia, PA 19129, USA.
³ Keck School of Medicine, University of Southern California, 1520 San Pablo Street, Los Angeles, CA 90033, USA.
⁴ Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.

Abstract

Imaging of musculoskeletal disorders, including arthritis, infection, osteoporosis, sarcopenia, and malignancies, is often limited when using conventional modalities such as radiography, computed tomography (CT), and MR imaging. As a result of recent advances in Positron Emission Tomography (PET) instrumentation, total-body PET/CT offers a longer axial field-of-view, higher geometric sensitivity, and higher spatial resolution compared with standard PET systems. This article discusses the potential applications of total-body PET/CT imaging in the assessment of musculoskeletal disorders.

Keywords: Arthritis; Cancer; Fever of unknown origin; Osteoporosis; Osteosarcoma; PET/CT; PET/MR imaging; Sarcopenia.

Publication types

Review

MeSH terms

Humans
Musculoskeletal Diseases / diagnostic imaging*
Musculoskeletal System / diagnostic imaging
Positron-Emission Tomography / methods*
Whole Body Imaging / methods*

Grants and funding

R01 AR076088/AR/NIAMS NIH HHS/United States