Economic evaluation plan of a RCT of hydroxyapatite-coated uncemented hemiarthroplasty versus cemented hemiarthroplasty for the treatment of displaced intracapsular hip fractures: the WHiTE5 trial

May Ee Png; Miguel A Fernandez; Juul Achten; Nicholas Parsons; Alwin McGibbon; Jenny Gould; Xavier Griffin; Matthew L Costa

doi:10.1302/2633-1462.13.BJO-2020-0003

Economic evaluation plan of a RCT of hydroxyapatite-coated uncemented hemiarthroplasty versus cemented hemiarthroplasty for the treatment of displaced intracapsular hip fractures: the WHiTE5 trial

Bone Jt Open. 2020 Mar 13;1(3):13-18. doi: 10.1302/2633-1462.13.BJO-2020-0003. eCollection 2020 Mar.

Authors

May Ee Png¹, Miguel A Fernandez², Juul Achten³, Nicholas Parsons⁴, Alwin McGibbon^{1

2

3

4

3}, Jenny Gould^{1

2

3

4

3}, Xavier Griffin³, Matthew L Costa³

Affiliations

¹ Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
² Oxford Trauma, NDORMS, University of Oxford, Oxford, UK; Trauma & Orthopaedic Surgery, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
³ Oxford Trauma, NDORMS, University of Oxford, Oxford, UK.
⁴ Statistics and Epidemiology Unit, Warwick Medical School, University of Warwick, Coventry, UK.

Abstract

Aim: This paper describes the methods applied to assess the cost-effectiveness of cemented versus uncemented hemiarthroplasty among hip fracture patients in the World Hip Trauma Evaluation Five (WHiTE5) trial.

Methods: A within-trial cost-utility analysis (CUA) will be conducted at four months postinjury from a health system (National Health Service and personal social services) perspective. Resource use pertaining to healthcare utilization (i.e. inpatient care, physiotherapy, social care, and home adaptations), and utility measures (quality-adjusted life years) will be collected at one and four months (primary outcome endpoint) postinjury; only treatment of complications will be captured at 12 months. Sensitivity analysis will be conducted to assess the robustness of the results.

Conclusion: The planned analysis strategy described here records our intent to conduct a within-trial CUA alongside the WHiTE5 trial.

Keywords: Cement; Economic; Hemiarthroplasty; Plan.

Abstract

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