Essential Tremor - A Cerebellar Driven Disorder?

Mohamed Fasil Ibrahim; Jessica C Beevis; Ruth M Empson

doi:10.1016/j.neuroscience.2020.11.002

Essential Tremor - A Cerebellar Driven Disorder?

Neuroscience. 2021 May 10:462:262-273. doi: 10.1016/j.neuroscience.2020.11.002. Epub 2020 Nov 17.

Authors

Mohamed Fasil Ibrahim¹, Jessica C Beevis², Ruth M Empson²

Affiliations

¹ Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand. Electronic address: ruth.empson@otago.ac.nz.
² Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.

PMID: 33212218
DOI: 10.1016/j.neuroscience.2020.11.002

Abstract

Abnormal tremors are the most common of all movement disorders. In this review we focus on the role of the cerebellum in Essential Tremor, a highly debilitating but poorly treated movement disorder. We propose a variety of mechanisms driving abnormal burst firing of deep cerebellar nuclei neurons as a key initiator of tremorgenesis in Essential Tremor. Targetting these mechanisms may generate more effective treatments for Essential Tremor.

Keywords: Purkinje neuron; deep cerebellar nuclei; essential tremor.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cerebellum
Essential Tremor*
Humans
Neurons
Tremor