Prostate Cancer Liver Metastases Presenting as Relatively Photopenic Lesions on 18F-Fluciclovine PET/CT

Clin Nucl Med. 2021 Apr 1;46(4):e240-e241. doi: 10.1097/RLU.0000000000003377.

Abstract

A 66-year-old man with prostate adenocarcinoma status post radical retropubic prostatectomy and bilateral pelvic lymph node dissection, followed by salvage external beam radiation therapy to the prostate bed 1 year after surgery. Over the course of 17 years, the patient underwent multiple lines of systemic treatment for recurrent disease. He was referred for restaging 18F-fluciclovine PET/CT due to rising serum prostate-specific antigen levels. Contrast-enhanced 18F-fluciclovine PET/CT images demonstrated multiple new liver metastases, which were relatively photopenic in comparison with the physiologic radiotracer activity in the surrounding normal liver parenchyma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carboxylic Acids*
  • Cyclobutanes*
  • Humans
  • Liver Neoplasms / diagnostic imaging*
  • Liver Neoplasms / secondary*
  • Male
  • Neoplasm Staging
  • Positron Emission Tomography Computed Tomography / methods
  • Prostate-Specific Antigen / blood
  • Prostatectomy
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / pathology*
  • Prostatic Neoplasms / surgery
  • Salvage Therapy

Substances

  • Carboxylic Acids
  • Cyclobutanes
  • fluciclovine F-18
  • Prostate-Specific Antigen