The Dueling Duo: IL10 and TNF Face Off in Microglial Recovery from Endotoxin Challenge

Paras Singh Minhas; Aarooran Sivakumaran Durairaj; Katrin I Andreasson

doi:10.1016/j.immuni.2020.10.016

The Dueling Duo: IL10 and TNF Face Off in Microglial Recovery from Endotoxin Challenge

Immunity. 2020 Nov 17;53(5):897-899. doi: 10.1016/j.immuni.2020.10.016.

Authors

Paras Singh Minhas¹, Aarooran Sivakumaran Durairaj¹, Katrin I Andreasson²

Affiliations

¹ Department of Neurology, Stanford University, Stanford, CA, USA.
² Department of Neurology, Stanford University, Stanford, CA, USA; Wu-Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA; Program in Immunology, Stanford University, Stanford, CA, USA. Electronic address: kandreas@stanford.edu.

PMID: 33207212
DOI: 10.1016/j.immuni.2020.10.016

Abstract

The molecular mechanisms that restore microglial quiescence after acute stimulation remain largely unexplored, unlike those that drive microglial activation. In this issue of Immunity, Shemer et al. discover that the microglial IL-10 receptor counteracts the pro-inflammatory effects of TNF to allow restoration of microglial quiescence after peripheral endotoxin challenge.

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MeSH terms

Endotoxins
Interleukin-10*
Microglia*

Substances

Endotoxins
Interleukin-10