First report of the aac(6')-Ib-cr gene in Providencia stuartii isolates in Brazil

Rev Soc Bras Med Trop. 2020 Nov 13:54:e20190524. doi: 10.1590/0037-8682-0524-2019. eCollection 2020.

Abstract

Introduction: The aac(6')-Ib-cr and bla KPC genes are spreading among Enterobacteriaceae species, including Providencia stuartii, in some countries of world.

Methods: These genes were investigated in 28 P. stuartii isolates from a public hospital in Recife, Pernambuco, Brazil, by PCR and sequencing.

Results: The aac(6')-Ib-cr gene was detected in 16 resistant isolates, and the bla KPC gene was seen in 14.

Conclusions: The presence of these genes in P. stuartii multi- and extensively drug-resistant isolates indicates that the resistance arsenal of this species is increasing, thus limiting the therapeutic options.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Brazil
  • Drug Resistance, Multiple, Bacterial
  • Enterobacteriaceae Infections*
  • Humans
  • Microbial Sensitivity Tests
  • Plasmids
  • Providencia
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • beta-Lactamases

Supplementary concepts

  • Providencia stuartii