Abstract
Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.
MeSH terms
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CRISPR-Associated Protein 9 / antagonists & inhibitors*
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CRISPR-Associated Protein 9 / genetics
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Gene Editing
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Gene Transfer Techniques
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Humans
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Male
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Metal-Organic Frameworks / chemistry
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Metal-Organic Frameworks / pharmacology*
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PC-3 Cells
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Prostatic Neoplasms / drug therapy*
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Prostatic Neoplasms / genetics
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RNA Interference / drug effects*
Substances
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Metal-Organic Frameworks
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CRISPR-Associated Protein 9