Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics

Anuva Rajappa; Sucharita Banerjee; Vivek Sharma; Piyush Khandelia

doi:10.3389/fmolb.2020.577938

Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics

Front Mol Biosci. 2020 Oct 28:7:577938. doi: 10.3389/fmolb.2020.577938. eCollection 2020.

Authors

Anuva Rajappa¹, Sucharita Banerjee¹, Vivek Sharma¹, Piyush Khandelia¹

Affiliation

¹ Department of Biological Sciences, Birla Institute of Technology and Science, Pilani - Hyderabad Campus, Hyderabad, India.

Abstract

Circular RNAs (circRNAs) are rapidly coming to the fore as major regulators of gene expression and cellular functions. They elicit their influence via a plethora of diverse molecular mechanisms. It is not surprising that aberrant circRNA expression is common in cancers and they have been implicated in multiple aspects of cancer pathophysiology such as apoptosis, invasion, migration, and proliferation. We summarize the emerging role of circRNAs as biomarkers and therapeutic targets in cancer.

Keywords: biomarkers; cancer; circRNAs; diagnostics; therapeutics.

Publication types

Review