Review of the Correlation of LAT1 With Diseases: Mechanism and Treatment

Jingshun Zhang; Ying Xu; Dandan Li; Lulu Fu; Xueying Zhang; Yigang Bao; Lianwen Zheng

doi:10.3389/fchem.2020.564809

Review of the Correlation of LAT1 With Diseases: Mechanism and Treatment

Front Chem. 2020 Oct 20:8:564809. doi: 10.3389/fchem.2020.564809. eCollection 2020.

Authors

Jingshun Zhang¹, Ying Xu¹, Dandan Li¹, Lulu Fu¹, Xueying Zhang¹, Yigang Bao¹, Lianwen Zheng¹

Affiliation

¹ Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China.

Abstract

LAT1 is a member of the system L transporter family. The main role of the LAT1 is to transport specific amino acids through cell membranes to provide nutrients to cells and participate in several metabolic pathways. It also contributes to the transport of hormones and some drugs, which are essential for the development and treatment of some diseases. In recent years, many studies have shown that LAT1 is related to cancer, obesity, diabetes, and other diseases. However, the specific mechanism underlying the influence of LAT1 on such conditions remains unclear. Through the increasing number of studies on LAT1, we have obtained a preliminary understanding on the function of LAT1 in diseases. These studies also provide a theoretical basis for finding treatments for LAT1-related diseases, such as cancer. This review summarizes the function and mechanism of LAT1 in different diseases and the treatment of LAT1-related diseases. It also provides support for the development of novel and reliable disease treatments.

Keywords: LAT1; MYC; cancer; immune diseases; insulin resistance; mTOR.

Publication types

Review