Numbers Game and Immune Geography as Determinants of Coronavirus Pathogenicity

Front Cell Infect Microbiol. 2020 Oct 23:10:559209. doi: 10.3389/fcimb.2020.559209. eCollection 2020.

Gennady Bocharov^{1

2

3}, Valentina Casella⁴, Jordi Argilaguet⁵, Dmitry Grebennikov^{1

2

3}, Roberto Güerri-Fernandez⁶, Burkhard Ludewig⁷, Andreas Meyerhans^{4

8}

¹ Marchuk Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow, Russia.
² Moscow Center for Fundamental and Applied Mathematics at Marchuk Institute of Numerical Mathematics, Russian Academy of Sciences (INM RAS), Moscow, Russia.
³ Institute for Personalized Medicine, Sechenov First Moscow State Medical University, Moscow, Russia.
⁴ Infection Biology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
⁵ Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, Bellaterra, Spain.
⁶ Infectious Diseases Unit, Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Barcelona, Spain.
⁷ Institute for Immunobiology, Kantonsspital St.Gallen, St. Gallen, Switzerland.
⁸ Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

No abstract available

Keywords: COVID-19; IFN-I; SARS - CoV-2; innate immunity; pathogenesis; viral dynamics.

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