Topology optimization of a mandibular reconstruction plate and biomechanical validation

David C Koper; Carine A W Leung; Lars C P Smeets; Paul F J Laeven; Gabriëlle J M Tuijthof; Peter A W H Kessler

doi:10.1016/j.jmbbm.2020.104157

Topology optimization of a mandibular reconstruction plate and biomechanical validation

J Mech Behav Biomed Mater. 2021 Jan:113:104157. doi: 10.1016/j.jmbbm.2020.104157. Epub 2020 Oct 28.

Authors

David C Koper¹, Carine A W Leung², Lars C P Smeets³, Paul F J Laeven³, Gabriëlle J M Tuijthof³, Peter A W H Kessler²

Affiliations

¹ Department of Cranio-Maxillofacial Surgery, Maastricht University Medical Center, PO Box 5800, 6202 AZ, Maastricht, the Netherlands; Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, PO Box 616, 6200 MD, Maastricht, the Netherlands; Department of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, PO Box 616, 6200 MD, Maastricht, the Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University, PO Box 616, 6200 MD, Maastricht, the Netherlands. Electronic address: d.koper@mumc.nl.
² Department of Cranio-Maxillofacial Surgery, Maastricht University Medical Center, PO Box 5800, 6202 AZ, Maastricht, the Netherlands.
³ Department of Instrument Design, Engineering and Evaluation, Maastricht University, PO Box 616, 6200 MD, Maastricht, the Netherlands.

PMID: 33187871
DOI: 10.1016/j.jmbbm.2020.104157

Abstract

Objectives: Reconstruction plates, used to bridge segmental defects of the mandible after tumor resection or traumatic bone tissue loss, are subjected to repeated stresses of mastication. High stress concentrations in these plates can result in hardware failure. Topology optimization (TO) could reduce the peak stress by computing the most optimal material distribution in a patient-specific implant (PSI) used for mandibular reconstruction. The objective of this study was biomechanical validation of a TO-PSI.

Methods: A computer-aided design (CAD) model with a segmental defect was created based on the geometry of a polyurethane mandible model. A standard-PSI was designed to bridge the defect. A TO-PSI was then designed with a maximum stress equal to the ultimate tensile stress of Ti6Al4V (930 MPa) during a loading condition of 378 N. Finite element analysis (FEA) was used to analyze stresses in both PSI designs during loading. The standard-PSI and TO-PSI designs were produced in triplicate by selective laser melting of Ti6Al4V, fixated to polyurethane mandible models with segmental defects identical to the CAD model, and subsequently subjected to continuous compression with a speed of 1 mm/min on a universal testing machine, while recording the load. Peak loads before failure in the TO-PSI group within a 30% range of the predicted peak load (378 N) were considered a successful biomechanical validation.

Results: Fracture of the TO-PSI occurred at a median peak load of 334 N (range 304-336 N). These values are within the 30% range of the predicted peak load. Fracture of the mandible model in the standard-PSI group occurred at a median peak load of 1100 N (range 1010-1460 N). Failure locations during biomechanical testing of TO-PSI and standard-PSI samples corresponded to regions in the FEA where stresses exceeded the ultimate tensile strength of titanium and polyurethane, respectively.

Conclusion: This study demonstrates a successful preliminary biomechanical validation of TO in the design process for mandibular reconstruction plates. Further work is needed to refine the finite element model, which is necessary to ultimately design TO-PSIs for clinical use.

Keywords: Biomechanical validation; Finite element analysis; Mandibular reconstruction; Patient-specific implant; Topology optimization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomechanical Phenomena
Bone Plates
Finite Element Analysis
Humans
Mandible
Mandibular Reconstruction*
Stress, Mechanical