A novel strategy via the triple process (multicomponent reactions (MCR)-domino)/tandem was developed for the synthesis of restricted and constrained bis-1,2,3-triazole-linked pyrrolo[3,4-b]pyridine peptidomimetics dimers in overall yields of 20-55%. This strategy allows the construction of six heterocycles in two stages of the reaction.
Keywords: CuAAC click; IMCR-based domino and tandem process; isocyanide-based multicomponent reactions; polyheterocyclic dimers; restricted and constrained peptidomimetics.