Characteristics of bakuchiol - the compound with high biological activity and the main source of its acquisition - Cullen corylifolium (L.) Medik

Nat Prod Res. 2021 Dec;35(24):5828-5842. doi: 10.1080/14786419.2020.1837813. Epub 2020 Nov 13.

Abstract

The article presents the characteristics of bakuchiol - a natural compound valuable in cosmetology and pharmacology. The only source for obtaining this specific meroterpenic phenol is the fruit of the species Cullen corylifolium (Psoralea corylifolia). Bakuchiol has recently been playing a significant role in cosmetology as a "natural substitute" for retinol, free of side effects.Clinical studies confirm valuable cosmetological properties of bakuchiol, such as anti-ageing, anti-pigmentation and anti-acne effects. Scientific research has also shown valuable pharmacological properties of bakuchiol, such as anti-cancer, hepatoprotective, cardioprotective, hypoglycemic, hypolipemic, and antidepressant. In addition, antioxidant, anti-inflammatory and antimicrobal activities of bakuchiol, valuable from the point of view of both cosmetology and therapy, have also been confirmed.A separate part of the article is devoted to the botanical, chemical and pharmacological characteristics of the species C. corylifolium as the main source for obtaining bakuchiol.

Keywords: Bakuchiol; Cullen corylifolium; Psoralea corylifolia; cosmetic properties; retinol; therapeutic effects.

MeSH terms

  • Fabaceae*
  • Phenols
  • Plant Extracts / pharmacology
  • Psoralea*

Substances

  • Phenols
  • Plant Extracts
  • bakuchiol