Objective: To investigate the prevalence of Toxoplasma gondii and Toxocara infections among pregnant women in Hangzhou City, so as to provide baseline data for decreasing birth defects and improving the population quality.
Methods: A total of 235 pregnant women receiving prenatal diagnosis at the First People's Hospital of Yuhang District during the period between February 2018 through December 2019 were recruited as the observation group, and 235 age-matched, non-pregnant healthy women at the same hospital during the same period served as the control group. The subjects'medical records were captured from the hospital management information system. Blood samples were collected from the observation and control groups and detected for the presence of IgG antibodies against T. gondii and Toxocara using an enzyme-linked immunosorbent assay (ELISA). The seroprevalence of the IgG antibodies against T. gondii and Toxocara was compared between the observation and control groups.
Results: The subjects in the observation group had a mean age of 26.5 ± 4.3 years (range, 23 to 31 years), and gestational ages of 10 to 27 weeks, and the subjects in the control group had a mean age of 26.1 ± 5.7 years (range, 20 to 30 years). The seroprevalence rates of IgG antibodies against T. gondii (28.51% vs. 4.68%; χ2 = 34.85, P < 0.01) and Toxocara (24.26% vs. 5.11%; χ2 = 25.77, P < 0.01) were both significantly higher in the observation group than in the control group, and the seroprevalence of T. gondii and Toxocara co-infections was also significantly greater in the observation group than in the control group (13.19% vs. 2.13%; χ2 = 17.49, P < 0.01).
Conclusions: The seroprevalence rates of T. gondii and Toxocara infections and their co-infections are all high among pregnant women in Hangzhou City. Screening of T. gondii and Toxocara infections is strongly recommended during pregnancy.
［摘要］ 目的 了解杭州市孕妇弓形虫和弓首线虫感染情况, 为降低出生缺陷、提高出生人口素质提供基础数据。方法 以 2018 年 2 月至 2019 年 12 月在杭州市余杭区第一人民医院妇产科接受产前诊断的 235 例孕妇作为观察组, 以同期 在该院体检中心接受健康体检且年龄相仿的 235 例健康未怀孕女性作为对照组, 通过医院管理信息系统收集两组病历 资料。采集两组研究对象血液样本, 采用酶联免疫吸附试验检测血清抗弓形虫和抗弓首线虫 IgG 抗体, 比较两组抗体检 出情况。结果 观察组年龄 23～31 岁, 平均年龄 (26.5 ± 4.3) 岁, 孕龄 10～27 周; 对照组年龄 20～30 岁, 平均年龄 (26.1 ± 5.7) 岁。观察组血清抗弓形虫IgG 抗体阳性率 (28.51% vs. 4.68%; χ2 = 34.85, P < 0.01) 、抗弓首线虫 IgG 抗体阳性率 (24.26% vs. 5.11%; χ2 = 25.77, P < 0.01) 均显著高于对照组。此外, 观察组抗弓形虫和抗弓首线虫IgG抗体双阳性检出 率亦显著高于健康对照组 (13.19% vs. 2.13; χ2 = 17.49, P < 0.01) 。结论 杭州市孕妇弓形虫、弓首线虫感染血清学阳性 率及两者合并感染率均较高, 应加强孕期弓形虫和弓首线虫感染筛查。.
Keywords: Co-infection; Hangzhou City; Pregnant woman; Serological survey; Toxocara; Toxoplasma gondii.