To date, studies have usually focused on the impact of abiotic factors on the distribution of plant pathogens and have built forecast models for the prediction of pathogen outbreaks. However, the impact of the combined effects of biotic and abiotic factors on the prevalence of economically important pathogens has usually been neglected. The objective of this study was to determine the relationship between powdery mildew and rusts of wheat and to examine how the combined effects of abiotic and biotic factors influence their prevalence. The study was conducted in the period 2016-2019 using the collection of 2158 genotypes of winter wheat. The most influential factors on disease indices and relationships among obligate pathogens were determined using multiple regression models and principal component analysis. The possibility of the coexistence of different rust species in the same growing season and in the same field was shown. The significant influence of fluctuations in winter temperatures on changes in the prevalence of obligate pathogens was determined. The strong impact of genotypes and their reaction on climatic elements in certain phenological stages were shown to be significant factors influencing the interactions among obligate pathogens and the predominance of one pathogen over another.